In the presence of these additives, calf zona fasciculata cells in primary culture synthesize aldosterone at rates which can approach those from cells isolated from the zona glomerulosa.
Calf zona glomerulosa cells rapidly lose the ability to synthesize aldosterone when placed in primary culture unless they are incubated in the presence of the antioxidants butylated hydroxyanisol and selenous acid, the radioprotectant DMSO, and the cytochrome P-450 inhibitor metyrapone. The glucocorticoids cortisol and corticosterone, depending upon the species, are synthesized in the inner cortex, the zona fasciculata.
Aldosterone production occurs in the outer area of the adrenal cortex, the zona glomerulosa.
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